areas of Interest
Hypertension
Hypertension, or an elevated blood pressure, is the leading modifiable risk factor for Cardiovascular Disease and affects almost 50% of the US population. Our laboratory investigates the mechanisms by which immune cell, particularly adaptive T cells, contribute to a hypertensive state and the associated tissue damage. We employ physiological and immunological techniques including in vivo blood pressure measurement, histology, flow cytometry, and multi-omic sequencing.
Heart Failure
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of new heart failure diagnoses. We are investigating immunological mechanisms that contribute to cardiac tissue remodeling.
Nanoparticle Development
T cells are notoriously difficult to provide targeted treatments. We are working with our collaborators to develop new strategies using nanoparticle technology to target these cells.
Metabolic Disease
A Western Diet is the primary lifestyle choice contributing to worldwide morbidity and mortality. We are looking to identify dietary changes that restore disrupted circadian patterns and reduce inflammation.
Rheumatoid Arthritis
Rheumatoid Arthritis is commonly associated with other cardiovascular diseases including hypertension. The link between these two is unknown, but we hypothesize that common immunological mechanisms contribute the development of both diseases.